Brijesh Kumar
CSIR-Central Drug Research Institute, India
Title: Evidence based research for quality control of Indian Medicinal Plants using HRMS and Hyphenated LC/MS instruments.
Biography
Biography: Brijesh Kumar
Abstract
Herbal medicines, also known as botanical medicines or phytomedicines, refer to the medicinal products of plant roots, leaves, barks, seeds, berries or flowers that can be used to promote health and treat diseases. Today, a vast range of drugs are either natural products or have been derived from them. Moreover increasing sales of herbal products indicate a worldwide concurrent surge of natural product use. Chemical fingerprinting has been demonstrated to be a powerful technique for the quality control of herbal medicines. A chemical fingerprint is a unique pattern that indicates the presence of multiple chemical markers within a sample. Similarly Natural products containing inherently large structural diversity are still a major source of bioactive agents. However many bioactive compounds have been re-discovered from new sources of natural products. To avoid it the identification of known leads at the early discovery step is highly desirable, a process known as dereplication. This method provides an efficient tool for rapid and precise identification of molecular formula of small molecules, with some characterization of sub structures, without a cumbersome process of compound isolation. Application of HRMS and hyphenated LCMS techniques for qualitative and quantitative study of bioactive phyto constituents in Indian Medicinal Plants/parts/products ( P.betle, A.paniculata, Ocimum and Rauvolfia ), with their variations and identification of makers will be discussed during the seminar.