Imran Ali Khan
King Saud University, Saudi Arabia.
Title: Genetic polymorphism Q192R of paraoxonase 1 is a conventional risk factor for type 2 diabetes mellitus in a Saudi population
Biography
Biography: Imran Ali Khan
Abstract
The paraoxonase 1 (PON1) gene polymorphism Q192R has been found to be consistent with multiple metabolic diseases comprising type 2 diabetes mellitus (T2DM). The R allele has been found to be associated with coronary artery disease and gestational diabetes in a Saudi population. Therefore, we attempted to determine the association between Q192R and T2DM in a Saudi population. Eight hundred subjects were enrolled in this case-control study, including T2DM patients (n = 400) and control individuals (n = 400). Epidemiological, clinical, and Q192R genotype data were obtained from all the subjects included in this study. Genotyping was performed by PCR-RFLP analysis followed by 12% polyacrylamide agarose gel electrophoresis. Most of the clinical characteristics of T2DM were associated with controls, having positive association with allele and genotype frequencies between the T2DM cases and controls (p < 0.05). Multiple regression analysis showed positive correlation of lipid profile with genotype (p < 0.05). The present findings provide robust evidence of PON1 Q192R polymorphism being associated with T2DM in a Saudi population.