Biologics and Biosimilars

Biography

Biography: Abdel Halim Harrath

Abstract

Gastric ulcers are part of a chronic relapsing disease that is well known to be a polyaetiologic chronic disease (Suleyman et al., 2001). Although many classic drugs are available to treat gastric ulcer, herbal medicines have triumphed as a diverse popular therapy and are emerging as an alternative to the available synthetic drugs (Ubaka et al., 2010). The aim of this study was to evaluate the ulceroprotective of essential oil extracted from the leaves of Juniperus. phoenicea (EOJp) against HCl/ethanol-induced ulcers in rats. The in vivo pre-treatment with EOJp at oral doses of 50, 75 and 100 mg/kg body weight has potent anti-ulcer activity, which justifies the ethnomedical claims about its significant gastroprotective effect. In fact, the pre-treatment with EOJp significantly decreased the malondialdehyde (MDA) content and increased the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). This effect may be related to an increase in the gastric mucosal defence mechanisms and the results of our study revealed histopathological maintaining of the integrity of the mucosa. As a result, the protective effect of the essential oil and its low toxicity requires further study to elucidate the mechanism of action and isolate the active principles. References Ubaka MC, Ukwe VC, Okoye CT, Adibe OM. Investigation into the antiulcer activity of aqueous extract of Aspilla africana. Asian. J. Medic. Sci., 2, 40–43 (2010). Suleyman H, Demirezer LO, Buyukokuroglu ME. Antiulcerogenic effect of Hippophae rhamnoides L. Phytother. Res., 625–627 (2001).