Ravindra Patel
OmniBRx Biotechnologies, India
Title: An overexploitation approach for cell culture based modular bioprocessing
Biography
Biography: Ravindra Patel
Abstract
In the battle of controlling healthcare costs, the high cost pharmaceuticals, especially biologics has become an important issue.
Successful production planning requires consideration of cost factors such as manufacturing cost, capital investment to build
new facilities or to retrofit existing ones, as well as the inventory costs. The cost attributed to the opportunity lost in selling the
product or failure to meet market demand is also considered as the inventory cost. Any unplanned downtime could severely affect the
customer service level, if facility utilization is too high. Underutilization of manufacturing facilities conversely suggests a misplaced
investment in capacity. The overexploitation approach was designed to mitigate the above described facility constrains due to its
power of combining the benefits of perfusion and fed batch processing mode with adequate elimination of facility constrains of fedbatch
bioprocessing was done. The key factors considered are: adapting to modular single use technologies for facility design; smallest
mall footprint for upstream processing saves initial investment, significantly; multiproduct facilities to be designed capable of offering
production output in kilograms per month; completely avoiding the use of conventional stainless steel bioreactors and culture revived
from single low-passage cell bank can be expanded for several months without compromising the product quality. With continuous
processing advantage while adapting an overexploitation approach, the cultured cells can be processed up to 60 passages, typically.